We conducted a disproportionality analysis in the World Health Organization pharmacovigilance database VigiBase to identify potential anticholinesterase drug candidates for repositioning in Alzheimer's disease (AD).ĭisproportionality analysis is a validated method for detecting significant associations between drugs and adverse events (AEs) in pharmacovigilance databases. Although several methods exist, the utility of pharmacovigilance databases for this purpose is unclear. Drug repositioning aims to propose new indications for marketed drugs.
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